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A calcium-binding motif that involves a loop of twelve amino acids with α-helices at each end. Members of the family include aequorin, *α-actinin, calbindin, calcineurin, calcyclin, calcyphosin, calmodulin, calpain, diacylglycerol kinase, fimbrin, myosin regulatory light chains, oncomodulin, osteonectin, spectrin, troponin C.

Subjects: Chemistry.

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