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(in protein synthesis)

The phase in which amino acids are linked together by sequentially formed peptide bonds to form a polypeptide chain (see translation). Elongation factors are proteins that – by binding to a tRNA-amino-acid complex – enable the correct positioning of this complex on the ribosome, so that translation can proceed. The key peptidyltransferase reaction required for formation of the peptide bond is catalysed not by a protein but by the large RNA subunit of the ribosome.

Subjects: Biological Sciences.

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