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A homodimeric glycoprotein (CD105, 658 aa) that is part of the TGFβ receptor complex, abundantly expressed on endothelial cell surfaces but also present on activated macrophages, fibroblasts, and smooth muscle cells. Endoglin is important in cardiovascular development and vascular remodelling and its cytoplasmic domain interacts with the actin cytoskeleton via zyxin-related protein 1 (ZRP-1). Defects in the endoglin gene cause hereditary haemorrhagic telangiectasia type 1.

Subjects: Medicine and Health — Chemistry.

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