Overview

endoglin


'endoglin' can also refer to...

endoglin

endoglin

Reduced angiogenic responses in adult endoglin heterozygous mice

Endoglin regulates renal ischaemia–reperfusion injury

Soluble endoglin antagonizes Met signaling in spindle carcinoma cells

Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin

Functional analysis of endoglin mutations from hereditary hemorrhagic telangiectasia type 1 patients reveals different mechanisms for endoglin loss of function

Analysis of several endoglin mutants reveals no endogenous mature or secreted protein capable of interfering with normal endoglin function

Is it the primetime for endoglin (CD105) in the clinical setting?

Endoglin in African Children with Plasmodium falciparum Malaria: A Novel Player in Severe Malaria Pathogenesis?

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2

Expression analysis of endoglin missense and truncation mutations: insights into protein structure and disease mechanisms

Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertension

Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia*

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration

The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras

P348Impaired macrophage polarization in endoglin haplo-insufficiency leading to defective tissue repair is recovered by counter balance the TGFbeta pathway

Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours

 

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Quick Reference

A homodimeric glycoprotein (CD105, 658 aa) that is part of the TGFβ receptor complex, abundantly expressed on endothelial cell surfaces but also present on activated macrophages, fibroblasts, and smooth muscle cells. Endoglin is important in cardiovascular development and vascular remodelling and its cytoplasmic domain interacts with the actin cytoskeleton via zyxin-related protein 1 (ZRP-1). Defects in the endoglin gene cause hereditary haemorrhagic telangiectasia type 1.

Subjects: Medicine and Health — Chemistry.


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