'endoglin' can also refer to...



Endoglin regulates renal ischaemia–reperfusion injury

Reduced angiogenic responses in adult endoglin heterozygous mice

Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin

Soluble endoglin antagonizes Met signaling in spindle carcinoma cells

Functional analysis of endoglin mutations from hereditary hemorrhagic telangiectasia type 1 patients reveals different mechanisms for endoglin loss of function

Analysis of several endoglin mutants reveals no endogenous mature or secreted protein capable of interfering with normal endoglin function

Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia*

Is it the primetime for endoglin (CD105) in the clinical setting?

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2

Expression analysis of endoglin missense and truncation mutations: insights into protein structure and disease mechanisms

Endoglin in African Children with Plasmodium falciparum Malaria: A Novel Player in Severe Malaria Pathogenesis?

Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertension

Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells

Up‐regulation of endoglin, a TGF‐β‐binding protein, in rats with experimental renal fibrosis induced by renal mass reduction

Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule*

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration


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Quick Reference

A homodimeric glycoprotein (CD105, 658 aa) that is part of the TGFβ receptor complex, abundantly expressed on endothelial cell surfaces but also present on activated macrophages, fibroblasts, and smooth muscle cells. Endoglin is important in cardiovascular development and vascular remodelling and its cytoplasmic domain interacts with the actin cytoskeleton via zyxin-related protein 1 (ZRP-1). Defects in the endoglin gene cause hereditary haemorrhagic telangiectasia type 1.

Subjects: Medicine and Health — Chemistry.

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