Overview

endophenotype


'endophenotype' can also refer to...

endophenotype

endophenotype

Autism Endophenotypes and Quantitative Trait Loci

Structural Cerebral Variations as Useful Endophenotypes in Schizophrenia: Do They Help Construct “Extended Endophenotypes”?

Neurophysiological Endophenotypes Across Bipolar and Schizophrenia Psychosis

Psychosis Endophenotypes in Schizophrenia and Bipolar Disorder

Neurocognitive endophenotypes of obsessive-compulsive disorder

Diagnostic Specificity of Neurophysiological Endophenotypes in Schizophrenia and Bipolar Disorder

Neural Endophenotypes of Social Behavior in Autism Spectrum Conditions

Endophenotypes in Schizophrenia for the Perinatal Period: Criteria for Validation

The Consortium on the Genetics of Schizophrenia: Neurocognitive Endophenotypes

Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures

Aging-3Towards a Cognitive Endophenotype Model of Preclinical Alzheimer's Disease

B-07Towards a Cognitive Endophenotype Model of Preclinical Alzheimer's Disease

The Consortium on the Genetics of Endophenotypes in Schizophrenia: Model Recruitment, Assessment, and Endophenotyping Methods for a Multisite Collaboration

Perceptual Pseudoneglect in Schizophrenia: Candidate Endophenotype and the Role of the Right Parietal Cortex

Comparison of the Heritability of Schizophrenia and Endophenotypes in the COGS-1 Family Study

Deconstructing Schizophrenia: An Overview of the Use of Endophenotypes in Order to Understand a Complex Disorder

Spatial Working Memory as a Cognitive Endophenotype of Schizophrenia: Assessing Risk for Pathophysiological Dysfunction

 

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A component part of a broad or complex phenotype. The concept was introduced in 1966 by population geneticists B. John and K. R. Lewis to refer to microscopic and internal phenotypes that are not apparent to the casual observer; since then it has been applied in medicine and psychiatry in efforts to unravel the genetic and physiological basis of multifactorial diseases, such as schizophrenia and heart disease. An endophenotype is thus a measurable and genetically determined aspect of a ‘bigger picture’. For example, cortisol secretion is an endophenotype of anxiety. Similarly, in evolutionary biology, complex traits, such as behaviours, can be regarded as the net result of the assembly of various modular endophenotypes.

Subjects: Biological Sciences.


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