eosinophil cationic protein

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A member of the RNase A superfamily, an arginine-rich protein (ECP, EC 3.1.27.-, ribonuclease 3, 160 aa) found in the granules of eosinophils and released when the cells are activated. The protein plays a role in the defence against helminths, e.g. it will damage schistosomula in vitro. Not the same as the MBP (major basic protein) of the granules. Serum levels of ECP have been used as a marker for allergic inflammation.

Subjects: Medicine and Health.

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