An exchange factor (Eph-interacting exchange factor that links the Eph receptor with rho GTPases and thus regulates actin remodelling in ‘forward signalling’. Ephexin1 binds to the kinase domain of the FGF-receptor mainly through its DH and PH domains. FGFR-mediated phosphorylation enhances the exchange activity toward rhoA. See Eph-related receptor tyrosine kinases.
Subjects: Medicine and Health.