Eph-related receptor tyrosine kinases

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A family of receptor tyrosine kinases (e.g. EphB2, formerly Nuk/Cek5/Sek3, 482 aa) that are involved in control of axonal navigation, neuronal fasciculation and vascular assembly. EPH receptors are activated by the binding of their cell-bound ligands (ephrins) on an adjacent cell. The ephrins in turn respond to binding of the Eph receptor, so signalling is bidirectional.

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