'ephrin' can also refer to...



Of Ephs and Ephrins: Companies Target Guidance Molecules in Cancer

Introduction to Eph/Ephrin Signaling in Vertebrate Development

The Role of Ephs and Ephrins in Memory Formation

Role of Eph/ephrin tyrosine kinase in malignant glioma

Ephrin A1 induces intercellular dissociation in Ishikawa cells: possible implication of the Eph–ephrin A system in human embryo implantation

P182Involvement of ephrin-A1 in the migration and proliferation of endothelial cells

Eph/ephrin reverse signalling induces axonal retraction through RhoA/ROCK pathway

P057 Soluble Ephrin-B2 is a Prognostic Biomarker of Pulmonary Fibrosis

Regional Differences in the Developing Cerebral Cortex Revealed by Ephrin-A5 Expression

3853Ephrin A1 modulates M2a polarization of macrophages and their migration potential

Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers

Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis: potential contribution to perturbed angiogenesis and fibrosis

37TNF-α mediated monocyte adhesion: role of ephrinA1 as potential link to atherosclerosis

Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis

Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis

WSS25 inhibits Dicer, downregulating microRNA-210, which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation

P002. Beneficial effects of blocking EphBs-ephrinBs forward signalling in a murine Crohn’s sisease (CD) model


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Membrane-achored ligands for the Eph-related receptor tyrosine kinases. Class A ephrins are GPI-anchored and bind to EphA receptors, ephrinBs are transmembrane and bind to EphB receptors and to EphA4. The consequence of an ephrin–Eph interaction depends on the cell type, but is often a repulsion cue, e.g. of the nerve growth cone. Binding leads to the formation of clusters of Ephs (on one cell) and ephrins (on the other) and the transmembrane ephrins becomes tyrosine phosphorylated on their cytoplasmic domains when they are bound by the receptor: both receptor and ligand respond to the binding interaction. This also seems to be true for the GPI-linked ephrins, although the reverse signalling mechanism presumably involves association with other signalling molecules in a lipid domain.

http://www.pantherdb.org/genes/geneList.do?searchType=basic&fieldName=all&listType=2&fieldValue=ephrin&organism=all The Panther database gives additional information on the ephrin family.

Subjects: Medicine and Health — Chemistry.

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