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A member (>700 kDa) of the plakin family of cytolinker proteins but somewhat atypical, having only plakin repeat domains and none of the other domains found in other plakins. It was originally identified as an autoantigen in serum from a patient with subepidermal blistering disease and it probably interacts with intermediate filaments. Its function is, however, unclear since its absence in mice does not lead to severe skin dysfunction.

Subjects: Medicine and Health.

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