epithelial mesenchymal transition

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'epithelial mesenchymal transition' can also refer to...

epithelial mesenchymal transition

The epithelial–mesenchymal transition (EMT) phenomenon

PARP-1 regulates epithelial–mesenchymal transition (EMT) in prostate tumorigenesis

Prognostic significance of epithelial–mesenchymal transition in malignant pleural mesothelioma,

Menstrual effluent induces epithelial–mesenchymal transitions in mesothelial cells

New insights of epithelial-mesenchymal transition in cancer metastasis

Cardiac Epithelial-Mesenchymal Transition Is Blocked by Monomethylarsonous Acid (III)

Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells

Cyclosporine A induced epithelial–mesenchymal transition in human renal proximal tubular epithelial cells

Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells

Epithelial to mesenchymal transition-like and mesenchymal to epithelial transition-like processes might be involved in the pathogenesis of pelvic endometriosis†

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

Epithelial–mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib

Epithelial–mesenchymal transition-associated secretory phenotype predicts survival in lung cancer patients

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

Network biology approach to epithelial–mesenchymal transition in cancer metastasis: three stage theory

HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition

La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition

Epithelial–mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions


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A developmental process in which epithelial cells are apparently reprogrammed and exhibit completely different behaviour. There is reduced adhesion, increased cell mobility, and loss of E-cadherin expression. The transition in behaviour is important in mesoderm formation and neural tube formation. The process is stimulated by various growth factors such as IGF-1 and TGFβ-1 and is regulated through the Ras-MAPK and Wnt signalling pathways. Ras-MAPK activates two related transcription factors, Snail and Slug, that are transcriptional repressors of E-cadherin and their expression induces EMT. Twist, another transcription factor, has also been shown to induce EMT, and is implicated in the regulation of metastasis.

Subjects: Medicine and Health.

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