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epithelial mesenchymal transition


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'epithelial mesenchymal transition' can also refer to...

epithelial mesenchymal transition

The epithelial–mesenchymal transition (EMT) phenomenon

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Cyclosporine A induced epithelial–mesenchymal transition in human renal proximal tubular epithelial cells

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Network biology approach to epithelial–mesenchymal transition in cancer metastasis: three stage theory

Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression

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Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

Epithelial–mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib

 

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A developmental process in which epithelial cells are apparently reprogrammed and exhibit completely different behaviour. There is reduced adhesion, increased cell mobility, and loss of E-cadherin expression. The transition in behaviour is important in mesoderm formation and neural tube formation. The process is stimulated by various growth factors such as IGF-1 and TGFβ-1 and is regulated through the Ras-MAPK and Wnt signalling pathways. Ras-MAPK activates two related transcription factors, Snail and Slug, that are transcriptional repressors of E-cadherin and their expression induces EMT. Twist, another transcription factor, has also been shown to induce EMT, and is implicated in the regulation of metastasis.

Subjects: Medicine and Health.


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