epithelial mesenchymal transition

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'epithelial mesenchymal transition' can also refer to...

epithelial mesenchymal transition

The epithelial–mesenchymal transition (EMT) phenomenon

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Menstrual effluent induces epithelial–mesenchymal transitions in mesothelial cells

Cardiac Epithelial-Mesenchymal Transition Is Blocked by Monomethylarsonous Acid (III)

Prognostic significance of epithelial–mesenchymal transition in malignant pleural mesothelioma,

Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells

Cyclosporine A induced epithelial–mesenchymal transition in human renal proximal tubular epithelial cells

Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells

Epithelial to mesenchymal transition-like and mesenchymal to epithelial transition-like processes might be involved in the pathogenesis of pelvic endometriosis†

P-210Detection of epithelial-mesenchymal transition in colorectal cancer in consideration of intratumor heterogeneity

24PCombination of temozolomide and cisplatin reduces epithelial to mesenchymal transition in glioma cells

Network biology approach to epithelial–mesenchymal transition in cancer metastasis: three stage theory

Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression

Epithelial-to-Mesenchymal Transition Is Important to Metastasis, But Questions Remain

Transcriptional and Post-transcriptional Regulation in TGF-β-mediated epithelial-mesenchymal transition

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

Epithelial–mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib


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A developmental process in which epithelial cells are apparently reprogrammed and exhibit completely different behaviour. There is reduced adhesion, increased cell mobility, and loss of E-cadherin expression. The transition in behaviour is important in mesoderm formation and neural tube formation. The process is stimulated by various growth factors such as IGF-1 and TGFβ-1 and is regulated through the Ras-MAPK and Wnt signalling pathways. Ras-MAPK activates two related transcription factors, Snail and Slug, that are transcriptional repressors of E-cadherin and their expression induces EMT. Twist, another transcription factor, has also been shown to induce EMT, and is implicated in the regulation of metastasis.

Subjects: Medicine and Health.

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