Microtubule-stabilizing compounds (16-member macrolides: epothilone A and B) originally isolated from myxobacterium Sorangium cellulosum Str 90. Their mode of action is similar to that of taxanes but the binding site is different and they can be used in treatment of tumours that are resistant to paclitaxel. Epothilone B has a threefold higher affinity for the taxoid binding site on β-tubulin than paclitaxel. A range of synthetic and semisynthetic analogues have been produced.
Subjects: Medicine and Health.