'epothilones' can also refer to...



Epothilones in breast cancer: review of clinical experience

Epothilones in prostate cancer: review of clinical experience

CME post-test for Epothilones Supplement

Potential clinical applications of epothilones: a review of phase II studies

Epothilone D affects cell cycle and microtubular pattern in plant cells

Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues

Peripheral blood mononuclear and tumor cell pharmacodynamics of the novel epothilone B analogue, ixabepilone

Novel neurosensory testing in cancer patients treated with the epothilone B analog, ixabepilone

Co-cultivation of Sorangium cellulosum strains affects cellular growth and biosynthesis of secondary metabolite epothilones

A phase II trial evaluating two schedules of sagopilone (ZK-EPO), a novel epothilone, in patients with platinum-resistant ovarian cancer

Phase I study of the novel, fully synthetic epothilone sagopilone (ZK-EPO) in patients with solid tumors

Phase I clinical study of the novel epothilone B analogue BMS-310705 given on a weekly schedule

Pilot study of epothilone B analog (BMS-247550) and estramustine phosphate in patients with progressive metastatic prostate cancer following castration

A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer

Engineering enzymes for improved catalytic efficiency: a computational study of site mutagenesis in epothilone-B hydroxylase


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Microtubule-stabilizing compounds (16-member macrolides: epothilone A and B) originally isolated from myxobacterium Sorangium cellulosum Str 90. Their mode of action is similar to that of taxanes but the binding site is different and they can be used in treatment of tumours that are resistant to paclitaxel. Epothilone B has a threefold higher affinity for the taxoid binding site on β-tubulin than paclitaxel. A range of synthetic and semisynthetic analogues have been produced.

Subjects: Medicine and Health.

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