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A conserved family of proteins (550–650 aa) that are essential components of the endocytotic machinery, bind phosphoinositides through an epsin N-terminal homology (ENTH) domain and interact with ubiquitin, clathrin, and endocytic scaffolding proteins through the C-terminal region. Epsin is thought to directly modify the curvature of membranes when it binds to phosphatidylinositol 4,5-bisphosphate (PIP2) A range of epsin-like proteins have been identified.

Subjects: Medicine and Health.

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