ergotamine tartrate

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The mycotoxin produced by Claviceps purpurea, a natural alkaloid that acts as an α-adrenergic blocking agent with a stimulatory effect on vascular smooth muscle of peripheral and cranial blood vessels and also causes depression of vasomotor centres. Ergotamine has serotonin antagonist properties. Used to relieve migraine by constricting cranial arteries.

Subjects: Clinical Pharmacology and Therapeutics.

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