A well-studied group of proteins because of the ease with which erythrocyte ghosts, essentially plasma membranes with associated cytoskeletal elements, can be prepared. The initial nomenclature was based upon the position of bands on an SDS polyacrylamide gel with band 1 (protein 1) being at the top, the largest protein. Subsequently the proteins in these bands became identified. Bands 1 and 2 are spectrin α and β respectively, band 2.1 is ankyrin, band III is the major anion transporter (solute carrier family 4, member 1), bands 4.1 and 4.2 are cytoskeletal linkers (see protein 4.1; protein 4.2). Band 4.5 is a nucleoside transporter, band 4.9 is dematin, band 5 is actin, band 6 is glyceraldehyde 3-phosphate dehydrogenase, and band 7 is stomatin.
Subjects: Medicine and Health.