1. An oncogene originally found in E26 transforming retrovirus of chickens (e26 transformation-specific sequence) that had the unusual property of inducing both myeloid and erythroid leukaemias. Subsequently found in a range of species including humans and was the ‘founder member’ of the ETS family of oncogenes and transcription factors defined by the presence of a conserved DNA binding domain recognizing a canonical…GGAA/T…sequence. The ETS domain is a DNA-binding domain, formed of three alpha-helices found in the DNA-binding domain of the human ETS-1 transcription factor.
2. External transcribed spacers. See internal transcribed spacers.
http://www.nature.com/onc/journal/v19/n55/pdf/1204046a.pdf Article ‘Ets and retroviruses’ in Oncogene (2000).