eukaryotic initiation factor

'eukaryotic initiation factor' can also refer to...

eukaryotic initiation factor

Crystallization and Preliminary X-Ray Diffraction Study of Recombinant Human Eukaryotic Initiation Factor-4E

Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A)


Phosphorylation of tobacco eukaryotic translation initiation factor 4A upon pollen tube germination

GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2α in Arabidopsis

Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter Disease

Crystal Structure of Hyperthermophilic Archaeal Initiation Factor 5A: A Homologue of Eukaryotic Initiation Factor 5A (eIF-5A)

Molecular Characterization and Phylogenetic Analysis of the Eukaryotic Translation Initiation Factor 4A Gene in Antheraea pernyi (Lipdoptera: Saturniidae)

A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter

Schwannomin inhibits tumorigenesis through direct interaction with the eukaryotic initiation factor subunit c (eIF3c)

Recognition of 5′-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2

Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing

Functional analysis of the interaction between HCV 5′UTR and putative subunits of eukaryotic translation initiation factor eIF3

The effect of heat shock protein 27 on extravillous trophoblast differentiation and on eukaryotic translation initiation factor 4E expression

Okadaic Acid Induces Apoptosis through Double-Stranded RNA–Dependent Protein Kinase/Eukaryotic Initiation Factor-2α Pathway in Human Osteoblastic MG63 Cells

Interference with Interaction between Eukaryotic Translation Initiation Factor 4G and Poly(A)-Binding Protein in Xenopus Oocytes Leads to Inhibition of Polyadenylated mRNA Translation and Oocyte Maturation

Domain-dependent Interaction of Eukaryotic Initiation Factor eIF4A for Binding to Middle and C-terminal Domains of eIF4G

The Post-Translational Synthesis of a Polyamine-Derived Amino Acid, Hypusine, in the Eukaryotic Translation Initiation Factor 5A (eIF5A)


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A multiprotein initiator factor complex (43S). eIF-1 is a low molecular weight factor (113 aa) critical for stringent AUG selection, eIF-2 has three subunits: α (315 aa), β (333 aa, a guanine nucleotide exchange factor), and γ (472 aa), and forms a ternary complex with Met-tRNAi and GTP. eIF-3 contains at least eight distinct polypeptides and plays a role in recycling of ribosomal subunits. eIF-4 is trimeric (eIF-4A, eIF-4E, and eIF-4G) and associates with the 5′ cap of mRNA. eIF-5 interacts with the 40S ribosomal initiation complex and promotes the hydrolysis of bound GTP and subsequent release of eIF-3 from the 40S subunit. The 40S subunit is then able to interact with the 60S ribosomal subunit to form the functional 80S initiation complex.

Subjects: Medicine and Health.

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