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Group of peptide hormones (39 aa), related to the glucagon family, found in the saliva of Gila monsters Heloderma suspectum, H. horridum. Helospectin is exendin-1; helodermin is exendin-2. Exendin-3 activates VIP receptors and stimulates amylase release from pancreatic acinar cells, whereas exendin-4 activates GLP-1 (glucagon-like peptide-1) receptors but has no effect on VIP receptors.

Subjects: Chemistry.

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