experimental allergic encephalomyelitis

Quick Reference


An animal model for demyelinating diseases in which an autoimmune response is induced by the injection of homogenized brain or spinal cord in Freund's adjuvant. The main antigen appears to be myelin basic protein, and the response is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, with demyelination and destruction of the blood-brain barrier. The validity of the model is uncertain.

Subjects: Medicine and Health.

Reference entries