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FACT


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An essential accessory factor for transcription when DNA is packaged in chromatin. Originally identified as an agent (facilitates chromatin transcription) required for RNA polymerase II to transcribe from nucleosomal DNA in vitro, but now recognized to be important in DNA replication and repair as well as transcription. It can also be considered as a histone chaperone. The highly conserved complex (~230 kDa) has two subunits, SSRP1 (structure-specific recognition protein, 709 aa), one of the high mobility group (HMG) protein family, and Cdc68 (SUPT16H, homologue of yeast Spt16, 1047 aa).

Subjects: Medicine and Health.


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