Overview

Fc


Related Overviews

 

'Fc' can also refer to...

 

More Like This

Show all results sharing this subject:

  • Medicine and Health

GO

Show Summary Details

Quick Reference

Region of the immunoglobulin molecule that binds to cells when the antigen-binding sites are occupied. Treatment of antibody with pepsin will release the Fc portion (fragment crystallizable) leaving the Fab2 fragment. Fc regions from the various antibody classes differ in their properties. Fc receptors are found on the surfaces of various cells involved in the immune response. There are five receptors for IgG: Fcγ-RI, -RII-A, -RII-B2, -RII-B1, and -RIII (CD16). FcγRII-B1 and FcγRII-B2 are inhibitory and their cytoplasmic domains have ITIM motifs. FcεRI binds IgE, FcαRI binds IgA. The consequences of receptor occupancy differ according to the receptor subtype.

Subjects: Medicine and Health.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.