An endemic virus that causes immunodeficiency and neurological defects in domestic cats Felix catus. FIV is a lentivirus related to two other feline retroviruses, feline leukaemia virus (FeLV), and feline foamy virus (FFV). FIV infects CD4+ and CD8+ T cells, B cells, and macrophages, using feline CD134 and CXCR4 as primary receptor and coreceptor respectively. The immunodeficiency may be due to failure to generate an IL-12-dependent type I response and excessive IL-10 production.
Subjects: Medicine and Health.