Overview

FERM domain


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A conserved domain (~150 aa) found in various proteins that link plasma membrane proteins to the cytoskeleton. The name derives from the four proteins in which it was first found: protein 4.1 (F), ezrin (E), radixin (R), and moesin (M). The ERM (ezrin–radixin–moesin) proteins are structurally and functionally highly homologous, with merlin/schwannomin, the NF2 tumour suppressor protein.

Subjects: Chemistry — Medicine and Health.


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