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fertilin


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Type I membrane glycoproteins (PH-30, ADAMs) in sperm membrane that are members of the ADAM family and bind to an integrin on the egg membrane, thus mediating sperm–egg adhesion. They are heterodimers; the α subunit (probably ADAM20, 726 aa, in humans, ADAM1 being a pseudogene) has homology to viral fusion peptides, the β subunit (ADAM2, 735 aa) has a tripeptide sequence involved in integrin binding.

Subjects: Medicine and Health.


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