A 2,871 amino acid glycoprotein associated with microfibrils about 10 nanometers in diameter. The protein is found in skin, tendon, bone, muscle, lung, kidney, blood vessels, and the suspensory ligament of the lens. Fibrillin contains 49 EGF domains. The protein is encoded by a gene symbolized by FBN1, and mutations in it are responsible for an inherited disease called Marfan syndrome (q.v.). See epidermal growth factor.
Subjects: Genetics and Genomics — Medicine and Health.