A thickening of the wall of an artery as a result of the accumulation of smooth muscle cells and fibrous tissue in the intima. The cells often have many fat globules (foam cells) and there may be extracellular lipid; fatty streaks may be precursors. If there is necrosis the thickening may be considered an atheroma. In extreme cases the lumen of the vessel may become occluded.
Subjects: Medicine and Health.