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ficolin


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ficolin

ficolins

Characterization of Ficolins as Novel Elastin-Binding Proteins and Molecular Cloning of Human Ficolin-1

New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei

Serum ficolin-2 correlates worse than fecal calprotectin and CRP with endoscopic Crohn's disease activity

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2

Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2

Ficolin-2 Levels and FCN2 Genetic Polymorphisms as a Susceptibility Factor in Schistosomiasis

Functional Haplotypes That Produce Normal Ficolin-2 Levels Protect against Clinical Leprosy

Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis

Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes

Mannose-binding lectin (MBL2) and ficolin-2 (FCN2) polymorphisms in patients on peritoneal dialysis with staphylococcal peritonitis

Increased titers of anti-Saccharomyces cerevisiae antibodies in Crohn's disease patients with reduced H-ficolin levels but normal MASP-2 activity

The Serum Opsonin L-ficolin Is Detected in Lungs of Human Transplant Recipients Following Fungal Infections and Modulates Inflammation and Killing of Aspergillus fumigatus

Low invasiveness of pneumococcal serotype 11A is linked to ficolin-2 recognition of O-acetylated capsule epitopes and lectin complement pathway activation

P141 Serum ficolin-2 correlates worse than fecal calprotectin and CRP with endoscopic Crohn's disease activity

Expression of H‐ficolin/Hakata antigen, mannose‐binding lectin‐associated serine protease (MASP)‐1 and MASP‐3 by human glioma cell line T98G

 

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A family of molecules (L-ficolin/P35, H-ficolin/Hakata antigen, M-ficolin, ~300 aa) that, together with mannose-binding lectin (MBL), act as immune sensors and activate the lectin complement pathway. When they bind to markers on microbial surfaces they trigger the cleavage of complement C4 by the serine peptidase MASP2 (MBL-associated serine protease-2). They are structurally similar to collectins, conglutinin, and surfactant proteins A and D and have a central collagen-like triple-helical region with a C-terminal fibrinogen-like domain. L- and H-ficolin are found in serum, M-ficolin in leucocytes. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis.

Subjects: Medicine and Health — Chemistry.


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