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Proteins isolated from caveolin-rich membrane domains. Flotillin 1 (reggie-2, 427 aa) and flotillin-2 (reggie-1, epidermal surface antigen-1, 428 aa) copurify with caveolin. See caveola. They have a prohibitin homology (PHB) domain, and are part of the SPFH (stomatin–prohibitin–flotillin-HflC/K) superfamily.

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