A method originally introduced in 1943 by Salvador Luria (1912–1991) and Max Delbrück (1906–1981) to estimate mutation rates in bacterial populations but subsequently applied to a variety of systems. A modified form of fluctuation analysis has been used to demonstrate that pre-existent and highly metastatic variant cells develop spontaneously within a tumour cell population. More sophisticated variations have been developed, e.g. detrended fluctuation analysis, which can be used to reveal long-range correlations in time series; nonstationary fluctuation analysis, which can be used to determine single-channel contributions to a macroscopic current even though the single channels cannot be studied directly.
http://www.bristol.ac.uk/synaptic/research/projects/NSFA.html More information on non-stationary fluctuation analysis.
Subjects: Medicine and Health.