Overview

flucytosine


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An antimetabolite that interferes with fungal DNA synthesis and is used against some strains of Candida and Cryptococcus. It is taken up via the cytosine permease and rapidly converted into fluorouracil by the enzyme cytosine deaminase once in the cytoplasm. TNs Ancobon, Ancotil.

Subjects: Clinical Pharmacology and Therapeutics.


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