focal adhesions

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'focal adhesions' can also refer to...

focal adhesions

focal adhesion kinase

Focal adhesion kinase and angiogenesis. Where do we go from here?

A new link between the retrograde actin flow and focal adhesions

Functional role of focal adhesion kinase in the process of implantation.

Focal Adhesion Kinase as a Potential Target in Arsenic Toxicity

Integrins and the cytoskeleton: focal adhesion kinase and paxillin.

Sodium Arsenite Exposure Alters Cell Migration, Focal Adhesion Localization and Decreases Tyrosine Phosphorylation of Focal Adhesion Kinase in H9C2 Myoblasts

Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice

Targeting Focal Adhesion Kinase and Resistance to mTOR Inhibition in Pancreatic Neuroendocrine Tumors

Role of the Focal Adhesion Protein Kindlin-1 in Breast Cancer Growth and Lung Metastasis

Focal Adhesion Kinase, Rap1, and Transcriptional Induction of Vascular Endothelial Growth Factor

Effects of the plasmid-encoded toxin of enteroaggregative Escherichia coli on focal adhesion complexes

Role of Focal Adhesion Kinase in Regulating YB–1–Mediated Paclitaxel Resistance in Ovarian Cancer

Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase

Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells

KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas

Estrogen receptor-α promotes endothelial cell motility through focal adhesion kinase


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Punctate adhesions (~1 × 0.2 μm) of cells with matrix-coated substratum, associated with intracellular microfilament bundles (stress fibres) and a complex of proteins such as vinculin and talin on the cytoplasmic face. They are oriented with the long axis parallel to the direction of movement and tend to be characteristic of slow-moving cells. Focal adhesion kinase (FAK; cytoplasmic protein tyrosine kinase, PTK2, EC, 1052 aa) is a kinase that is concentrated in focal adhesions. It is activated by phosphorylation, primarily by src-kinase, and activity is important for spreading and motility of fibroblasts, neurites and myocytes. A related kinase is PYK2.

Subjects: Medicine and Health.

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