An activin antagonist (344 aa) that inhibits the secretion of follicle stimulating hormone. Not a member of the inhibin family. Has three follistatin domains, which are presumed to be growth factor binding motifs. Follistatin-like 1 (follistatin-related protein, 308 aa) appears to act on macrophages to increase TNF and IL-1β production and IL-6 activity. Follistatin-like-3 (263 aa) is an extracellular matrix-associated glycoprotein thought to bind morphogens or growth/differentiation factors and regulate their activity during development.
Subjects: Medicine and Health.