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'forkhead' can also refer to...



Introduction to Forkhead Genes

forkhead box protein

Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis

The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin-mediated cytotoxicity

The Yeast Forkhead HCM1 Controls Life Span Independent of Calorie Restriction

Essential structural and functional determinants within the forkhead domain of FOXC1

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain

Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF


Mutational probing of the forkhead domain of the transcription factor FOXL2 provides insights into the pathogenicity of naturally occurring mutations

Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease

Missense mutations in the forkhead domain of FOXL2 lead to subcellular mislocalization, protein aggregation and impaired transactivation

Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis

Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1

Pleiotropic Skeletal and Ocular Phenotypes of the Mouse Mutation Congenital Hydrocephalus (ch/Mf1) Arise from a Winged Helix/Forkhead Transcription Factor Gene

Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts

Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor κB and Forkhead Box O Phosphorylation


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Originally the product of the Drosophila homeobox gene fork head, a transcription factor. Subsequently many related transcription factors have been identified, and are now reclassified as forkhead box proteins (Fox proteins) with subclasses ranging from FoxA to FoxS. All are winged-helix transcription factors containing the forkhead box motif that binds DNA, and are involved in cell growth, proliferation, differentiation, longevity and embryonic development. The forkhead activin signal transducer (FAST, FoxH1, 365 aa) is expressed in most human tissues including breast, colon, thymus, and muscle, and in several cancer cell lines. It binds to SMAD2 and activates an activin response element. Forkhead homologue in rhabdomyosarcoma (FKHR, forkhead receptor, FoxO1, 655 aa) is translocated and fused with PAX3 or PAX7 in alveolar rhabdomyosarcomas. Activation in many cells induces cell cycle arrest followed by apoptosis but this is blocked when FKHR is phosphorylated by protein kinase B (Akt) which causes it to be transported to the cytoplasm. FKHR can interact with both steroid and nonsteroid nuclear receptors and, depending on the receptor, can act as either a coactivator or corepressor. Forkhead transcription factor in rhabdomyosarcoma like-1 ( FKHRL1, 673 aa) is related to FKHR and has a role in the regulation of the proliferation of vascular smooth muscle. See Fox.

Subjects: Medicine and Health.

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