Forssman antigen

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A glycolipid heterophile antigen (globopentosylceramide) expressed on cell surfaces during embryonic and adult life in rodents and other mammals but probably not in humans. Anti-Forssman antibodies directed against the terminal sugar moiety are commonly found in plasma and may be involved in Guillain–Barré syndrome. Anti-Forssman antibodies also reportedly disrupt tight junction formation, apical–basal polarization, and cell adhesion.

Subjects: Chemistry — Medicine and Health.

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