The leucine zipper protein (380 aa) that dimerizes with jun to form the AP-1 transcription factor. Originally identified as the product of the v-fos oncogene of the Finkel–Biskis–Jenkins and Finkel–Biskis–Reilly murine osteogenic sarcoma retroviruses. The fos gene family has four members: FOS, FOSB, fos-related antigen-1 (FRA1; fos-like antigen-1, Fosl-1), and fos-related antigen-2 (FRA2), all of which can dimerize with members of the jun family. Fra-1 lacks the transactivation domains so will suppress AP-1 activation.
Subjects: Chemistry — Medicine and Health.