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'fractalkine' can also refer to...


Fractalkine: a novel cardiac chemokine?

Fractalkine in rheumatoid arthritis: a review to date

Detrimental effect of fractalkine on myocardial ischaemia and heart failure

Fractalkine (FRK) levels in amniotic fluid and its production during pregnancy

Expression of fractalkine in the Fallopian tube and of CX3CR1 in sperm

Detection of fractalkine in human seminal plasma and its role in infertile patients

Advanced glycation end-product induces fractalkine gene upregulation in normal rat glomeruli

Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia

Fractalkine has anti-apoptotic and proliferative effects on human vascular smooth muscle cells via epidermal growth factor receptor signalling

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis

Role of CX3C-chemokine CX3C-L/fractalkine expression in a model of slowly progressive renal failure

Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats

493 Increased expression of Fractalkine (CX3CL1) in endomyocardial biopsies from patients presenting with acute myocarditis

Increased expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in Wegener's granulomatosis—possible role in vascular inflammation

Expression of fractalkine in the rat testis: molecular cloning of a novel alternative transcript of its gene that is differentially regulated by pro‐inflammatory cytokines

CX3CL1 and CX3CR1 expression in tertiary lymphoid structures in salivary gland infiltrates: fractalkine contribution to lymphoid neogenesis in Sjögren’s syndrome

DOP056 Efficacy and safety of anti-fractalkine monoclonal antibody, E6011, in patients with Crohn’s disease who had lost response to anti-TNFα agents: A multicentre, open-label, Phase 1/2 study


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An unusual membrane-anchored chemokine (FK, CX3CL1, SCYD1, neurotactin, 397 aa) that differs from others in having a CXXXC motif. It is mostly expressed in the brain where it is up-regulated on capillary endothelium and microglia in inflammation and EAE. It binds to cells expressing the chemokine receptor CX3CR1. Soluble active fragments (76 aa) generated by TNFα converting enzyme (TACE) are chemotactic for T cells, NK cells, and monocytes.

Subjects: Medicine and Health.

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