An unusual membrane-anchored chemokine (FK, CX3CL1, SCYD1, neurotactin, 397 aa) that differs from others in having a CXXXC motif. It is mostly expressed in the brain where it is up-regulated on capillary endothelium and microglia in inflammation and EAE. It binds to cells expressing the chemokine receptor CX3CR1. Soluble active fragments (76 aa) generated by TNFα converting enzyme (TACE) are chemotactic for T cells, NK cells, and monocytes.
Subjects: Medicine and Health.