Overview

fragile histidine triad protein


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(FHIT)

An AP3A (diadenosine triphosphate) hydrolase thought to be involved in regulation of DNA replication and signalling stress responses. The conserved histidine triad residues are required for enzymatic activity. FHIT is inactivated in various tumours and FHIT is a target for src-kinase.

Subjects: Medicine and Health.


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