The multisubunit proton-transporting ATPase (F1/Fo ATPase, ATP synthase, F-ATPase), that is normally driven in reverse by a proton gradient to produce ATP (chemiosmosis). It is found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. The transmembrane Fo sector of the enzyme contains a rotary motor that is fuelled by the proton gradient; rotation is transmitted via a central stalk to the catalytic subunits in the soluble F1 domain, where conformational changes induced by the rotation enable the synthesis and subsequent release of ATP. Vacuolar (V-type) ATPases are related but operate in reverse and use ATP to pump protons.
http://www.bio.davidson.edu/Courses/Molbio/MolStudents/spring2003/Bennett/protein1.htm Additional detail in a website produced as an assignment for an undergraduate course at Davidson College, North Carolina.
Subjects: Medicine and Health.