Overview

functional cloning


'functional cloning' can also refer to...

functional cloning

functional cloning

functional cloning

functional cloning

Molecular Cloning and Functional Analysis of Sialyltransferases

Cloning, Tissue Distribution, and Functional Characterization of Chicken Glucagon Receptor

Cloning and functional characterization of carotenoid cleavage dioxygenase 4 genes

Molecular cloning and functional characterization of guinea pig IL-12

Molecular cloning and functional analysis of two polyhydroxyalkanoate synthases from two strains of Aeromonas hydrophila spp.

Cloning and characterization of a haloarchaeal heat shock protein 70 functionally expressed in Escherichia coli

Cloning and functional characterization of the ambler Class C β-lactamase of Yersinia ruckeri

Molecular cloning and functional characterisation of a glucose transporter, CaHGT1, of Candida albicans

Cloning, expression, and functional characterization of the Mycobacterium tuberculosis secA gene

Cloning, functional expression and partial characterization of the glucose kinase from Renibacterium salmoninarum

Molecular Cloning and Functional Analysis of ESGP, an Embryonic Stem Cell and Germ Cell Specific Protein

Purification, cloning and functional characterization of a fructan 6-exohydrolase from wheat (Triticum aestivum L.)

Cloning, functional expression, and characterization of a chalcone 3-hydroxylase from Cosmos sulphureus

Molecular Cloning and Functional Characterization of the Upstream Promoter Region of the Human p73 Gene

Molecular Cloning and Functional Expression of the Human Golgi UDP-N-Acetylglucosamine Transporter

 

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In human genetics, the identification of the gene responsible for a disease from a knowledge of the underlying molecular defect. If the protein encoded by the gene is known, it is often possible to isolate the appropriate mRNAs and to use them, or cDNAs derived from them, as probes for the gene. This was the first method used successfully to clone genes responsible for certain hereditary diseases, such as sickle cell anemia, Tay-Sachs disease, and phenylketonuria. Contrast with positional cloning. See cDNA, hereditary disease, mRNA, probe.

Subjects: Chemistry.


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