One of the pair rule selector genes of Drosophila. The name means segment deficient in Japanese. The ftz gene is located at 3–47.5, within the Antennapedia complex, and it is first expressed within 7 vertical stripes of cells in the early embryo. It has later functions during metamorphosis when it specifies the identities of individual neurons in the developing central nervous system. FTZ, the protein encoded by ftz, contains a PEST sequence (q.v.) and a homeobox (q.v.). FTZ functions as an activator of the transcription of segment polarity genes such as engrailed. But FTZ can also function as a suppressor of transcription for genes such as wingless. See zygotic segmentation mutants.
Subjects: Genetics and Genomics.