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gankyrin


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An antiapoptotic oncoprotein (PSMD10, p28, 226 aa) containing seven ankyrin repeats that is overexpressed early in hepatocarcinogenesis and in hepatocellular carcinomas. Gankyrin interacts with S6 ATPase of the 19S regulatory particle of the 26S proteosome, regulates the phosphorylation of the retinoblastoma protein (pRb) by CDK4, enhances the ubiquitylation of p53 by the RING ubiquitin ligase MDM2, and inhibits NFκB activity.

Subjects: Medicine and Health.


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