Overview

GARPs


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Multivalent proteins (glutamic-acid-rich proteins), that interact with the cGMP phosphodiesterase, guanylate cyclase, and the retina-specific ATP-binding cassette cation transporter (the cGMP-gated channel) that together comprise the amplification system of the rod photoreceptors, sometimes called the transducisome. They exist as two soluble forms, GARP1 and GARP2, and as a large N-terminal cytoplasmic domain (GARP′ part). GARP2, the predominant splice variant of the β subunit, associates with light-activated phosphodiesterase and inhibits the breakdown of cGMP. Mutations in the gene can lead to autosomal recessive retinitis pigmentosa.

Subjects: Medicine and Health.


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