Carcinoma of the stomach, probably the second most common carcinoma. Several genes may be associated with an increased risk of gastric cancer and there are various inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (see GTBP); familial adenomatous polyposis (polyposis coli); Peutz–Jeghers syndrome; Cowden's disease; Li–Fraumeni syndrome). One form of familial gastric cancer is caused by germline mutations in the E-cadherin gene, others by somatic mutations in a range of genes. Only ~10% of cases have a clear hereditable component and other important factors include diet, infection with Helicobacter pylori, and gastritis.
Subjects: Medicine and Health.