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gelsolin


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Actin-binding protein (brevin, actin depolymerizing factor, 782 aa) that nucleates actin polymerization and severs microfilaments at sub-micromolar calcium concentrations. A variant with an additional N-terminal 23 aa is found in plasma and probably clears actin from the circulation. The amyloid protein in the Finnish type of hereditary amyloidosis is a fragment of gelsolin with a single mutated amino acid.

Subjects: Chemistry — Medicine and Health.


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