Morphologically distinct regions that develop within lymphoid organs following activation of B cells. They contain large numbers of antigen presenting cells (follicular dendritic cells) as well as proliferating B cells (centroblasts), some nondividing B cells (centrocytes) and a few T cells. Plasma cells and memory B cells are generated in the germinal centres. Germinal centre kinase (mitogen-activated protein kinase kinase kinase kinase, MAP4K2, EC 18.104.22.168, 820 aa) is a STE20-like serine/threonine kinase that is activated by TNFα, activates the SAPK pathway, and will inactivate CLH-3 chloride channel. The germinal centre kinases (GCKs) are a subfamily of STE20-like kinases that include MINK1, Traf2-, and Nck-interacting kinase (TNIK), SOK1. Germinal centre kinase-like kinase (HGK, hepatocyte progenitor kinase-like kinase, MAP4K4, 1239 aa) activates JNK and is upstream of mTOR.
Subjects: Medicine and Health.