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A protein (597 aa) that is thought to be important in the crosstalk between the intermediate filament and microtubule networks. One of the cytoskeletal BTB/kelch (broad-complex, tramtrack, and bric-a-brac) repeat family. It controls protein degradation and is essential for neuronal function and survival. Gigaxonin binds to the ubiquitin-activating enzyme E1 and interacts with microtubule-associated protein-1B. Mutations lead to giant axonal neuropathy.

Subjects: Medicine and Health.

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