A family of homo- and hetero-oligomeric potassium channels (G-protein-gated inward rectifying potassium channels) composed of different subunits (GIRK1–4 in mammals). GIRK4 (KIR3.4) and GIRK1 (KIR3.1) are found mainly in the atrium, whereas neuronal cells predominantly express the GIRK1, GIRK2, and GIRK3 isoforms. They are activated through direct interactions of their cytoplasmic N- and C-terminal domains with G protein β-γ subunits. The anaesthetic halothane is thought to interact with these channels. A point mutation in the GIRK2 gene in weaver (wv) mutant mice causes neurological and reproductive defects.
Subjects: Medicine and Health.