Glanzmann's thrombasthenia

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An autosomal recessive bleeding disorder in which platelet aggregation is deficient because the β3 integrin (glycoprotein IIb/IIIa) is absent or present at reduced levels. The disorder can be caused by mutation in the gene of either one of the two glycoproteins that constitute the fibrinogen receptor. A possible autosomal dominant form has been reported.

Subjects: Medicine and Health.

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