Related Overviews


'GLA' can also refer to...

Eochu Glas

George Glas (1725—1765) mariner




Glas Ghaibhleann

Goídel Glas

Inber Glas

John Glas (1695—1773) founder of the Glasite or Sandemanian church

matrix Gla protein

Steele Glas


More Like This

Show all results sharing this subject:

  • Medicine and Health


Quick Reference

1. γ-linolenic acid.

2. Galactosidase-α (EC, GLA, 429 aa), the gene for which is defective in Fabry's disease.

3. Gla proteins are found in bone (bone Gla protein or osteocalcin) and matrix (matrix Gla protein). Gla proteins are post-translationally modified by glutamate carboxylase, which mediates the conversion of glutamate to γ-carboxyglutamate (Gla) with vitamin K as a cofactor. The γ-carboxylation of the Gla proteins is essential for the proteins to attract calcium ions and to incorporate these into hydroxyapatite crystals. The gla-domain, nine to twelve residues of Gla distributed over a ~45-aa peptide sequence, is found in vitamin K-dependent coagulation plasma proteins where it is important in binding calcium.

Subjects: Medicine and Health.

Reference entries