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GLA


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1. γ-linolenic acid.

2. Galactosidase-α (EC 3.2.1.22, GLA, 429 aa), the gene for which is defective in Fabry's disease.

3. Gla proteins are found in bone (bone Gla protein or osteocalcin) and matrix (matrix Gla protein). Gla proteins are post-translationally modified by glutamate carboxylase, which mediates the conversion of glutamate to γ-carboxyglutamate (Gla) with vitamin K as a cofactor. The γ-carboxylation of the Gla proteins is essential for the proteins to attract calcium ions and to incorporate these into hydroxyapatite crystals. The gla-domain, nine to twelve residues of Gla distributed over a ~45-aa peptide sequence, is found in vitamin K-dependent coagulation plasma proteins where it is important in binding calcium.

Subjects: Medicine and Health.


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