The enzyme (GAPDH, GAPD, G3PD, EC 220.127.116.11, 335 aa) that catalyses the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate, the three-carbon intermediate of the glycolytic pathway formed by the cleavage of fructose 1,6-bisphosphate by aldolase. GAPDH interacts with various elements of the cytoskeleton, and with the trinucleotide repeat in the huntingtin gene. A testis-specific isoform (GAPD2) has been identified. Genetic variation in members of the GAPD gene family may be risk factors in Alzheimer's disease.
Subjects: Medicine and Health.