glycogen synthase kinase

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'glycogen synthase kinase' can also refer to...

glycogen synthase kinase‐3

glycogen synthase α kinase

glycogen synthase kinase

Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics

Acute ethanol challenge inhibits glycogen synthase kinase-3β in the rat prefrontal cortex

Not only lithium: regulation of glycogen synthase kinase-3 by antipsychotics and serotonergic drugs

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease

Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3

Glycogen Synthase Kinase-3β, NF-κB Signaling, and Tumorigenesis of Human Osteosarcoma

Glycogen synthase kinase-3β is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts

Dual effects of increased glycogen synthase kinase-3β activity on adult neurogenesis

Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy

Involvement of Glycogen Synthase Kinase-3β in Arsenic Trioxide–Induced p21 Expression

c-Src regulates cell cycle proteins expression through protein kinase B/glycogen synthase kinase 3 beta and extracellular signal-regulated kinases 1/2 pathways in MCF-7 cells

Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3β activation

Altered Wnt signalling in the teenage suicide brain: focus on glycogen synthase kinase-3β and β-catenin

Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania

Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis

Role of Glycogen Synthase Kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus


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A serine/threonine protein kinase (GSK, EC present in two isoforms, GSK3-α (483 aa) and -β (420 aa), that is constitutively active in resting cells and is a negative regulator in various intracellular signalling pathways. Levels of GSK are rapidly reduced by insulin and various growth factors, releasing a constraint, and GSK is involved in the control of glycogen metabolism and protein synthesis by insulin, the modulation of AP1 and CREB, the specification of cell fate in Drosophila and the regulation of dorsoventral patterning in Xenopus. In Drosophila GSK3 (zeste-white 3/shaggy) functions as a negative regulator of the Wnt/β-catenin pathway. GSK3 itself is regulated by PKB. GSK3 is identical to tau protein kinase I and may therefore be important in the phosphorylation of tau that is known to occur in the neurofibrillary tangles of Alzheimer's disease.

Subjects: Medicine and Health — Chemistry.

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